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Laboratory for Marine Chemicobiology
Dr Chih-Chuang Liaw's Lab

at Department of Marine Biotechnology and Resources, National Sun Yat-sen University

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Lecture Handout

 

General Biology 2018

     General Biology is an basic subject for life science, and is also a compulsory subject in Department of Marine Biotechnology and Resources. In the class, five parts will be introduced for the fresh men in the department, including the Chemistry in Biology, Cell and Genetic inheritance, Phytology, Zoology, and Evolution.

TextBook: Campbell Biology, A Global Approach 11e (2016), Pearson Publisher

 

Lecture 1

Biology and Its Theme

2018, 1029 upload

Lecture 2

Atoms and Molecules

2018, 1029 upload

Lecture 3

The Chemistry of Water

2018, 1029 upload

Lecture 4

Carbon: the Basis of Molecular Diversity

2018, 1029 upload

Lecture 5

Biological Macromolecules and Lipids

2018, 1029 upload

Lecture 6

Energy and Life

2018, 1029 upload

Lecture 7

Cell structure and function

2020, 1025 upload

Lecture 8

Cell

membrane

2020, 1025 upload

Lecture 7

Cellular signaling

2018, 1029 upload

Lecture 8

Cell Respiration

2018, 1029 upload

Lecture 9

Photosynthetic Processes

2018, 1029 upload

Lecture 9

Mitosis

2018, 1029 upload 

 

 

Lecture 11

Sexual life Cycles and Meiosis

2018, 1029 upload

   

 

Introduction to Traditional Medicine from the Sea (2011)

      Marine drugs is one important part of natural medicinal products. Abundant diversity of marine organisms is the treasure resources of novel natural products. In the class, I will introduce the basic knowledge on the principles of traditional Chinese medicine, further development and combination with modern medicine.

      TextBook: 中藥學概論, 張永勳、何玉玲、黃世勳, 文興出版 (2008); 功能海洋生物分子, 譚仁祥等編著, 科學出版社 (2006).

      Handout:

Lecture 1

Introduction to TCM

2023, 0318 upload

Lecture 2

Theoretical Principle of TCM

2023, 0318 upload

Lecture 3

Manufacture of TCM

2023, 0318 upload

Lecture 4

Chemistry and Use of TCM

2023, 0318 upload

 

Lecture 5

Pharmacology of TCM

part1

2023, 0524 upload

Lecture 6

Pharmacology of TCM

part2

2023, 0524 upload

Lecture 7

Pharmacology of TCM

part3

2023, 0524 upload

Lecture 8

Pharmacology of TCM

part4

2023, 0524 upload

Lecture 9

Pharmaceutical

History

2012, 0619 upload

 

Lecture 10

Marine Algae in TCM

2013, 0603 upload

 

Lecture 11

Marine Animal in TCM

2011, 0604 upload

 

 

 

Introduction to Marine Chemcial Biology (2011)

     

      Textbook: Essentials of Chemical Biology- Structure and Dynamics of Biological Macromolecules, by Andrew Miller, John Wiley & Sons Ltd (2008)

      Handout:

Lecture 1

Introduction to Chemical Biology

2011, 0314 upload

Lecture 2

Marine and Chemical Biology

2011, 0314 upload

Lectures 3&4

The Structures of Biological Macromolecules and Lipid Assemblies

Part IPart II

2011, 0314 upload

2011, 0411 upload

Lecture 5

Chemical and Biological Synthesis

Part I, Part II

2011, 0411 upload

2011, 0603 upload

Lecture 6

Electronic Spectroscopy

2011, 0603 upload

Lecture 7

Resonance Spectroscopy

2011, 0621 upload

 

 

 

 

Marine Natural Products (2011)

     

      Textbook: Natural Product Chemistry, by Kurt B. G. Torssell, Swedish Pharmaceutical Press (1997)

      Handout:

 

Lecture 1

Introduction to Natural Products Chemistry

 

Lecture 2

Reseach Methology on Natural Products Chemistry

2011, 0314 upload

Lectures 3&4

Amino acids, Peptides and Alkaloids

2011, 0411 upload

 

 

Lecture 5

Alkaloids

2011, 0603 upload

Lecture 6

Lecture 7

 

 

 

 

Note for Seminar in DMBR/NSYSU

    How to make a presentation

 

Natural Products Chemistry

      In contrary to primary metabolites, secondary metabolites, also named as natural products, are those chemical compounds of metabolism that are not essential for normal growth, development or reproduction of an organism. These secondary metabolites exactly play an important role in life. The function or importance of these metabolites to the organism's development in ecological nature is well-established to be defense against predators, for interspecies competition, and to facilitate the reproductive processes. Secondary metabolites also present multifunctions in the bodies of life organism, such as the signal transmitter. The absence, deficiency or excessive amount of these secondary metabolites would make our organs dysfunctions. For example, Alzheimer disease is relative to the absence of dopamine.

      Plant secondary metabolites are of tremendous importance, both for the plant itself (for plant-environment interactions) and for humans due to their biological activities that can have therapeutic value. As we know, plants have a long history of use in the treatment of human disease. One of the famous examples is traditional Chinese medicine (TCM), the quintessence of herb material medics that Chinese people have been used for centuries. Now, the botanical extracts of TCM have been regarded as a source of new and useful pharmaceutical. Many bioactive components have been identified from these herb materials under the effort of natural product chemists. They are also regarded as a target for synthetic organic chemists that can produce these molecules in vitro on larger scales.

 

     The class should be taken by the students who has learned gerenal chemistry, organic chemistry, and biochemistry. In the class, I will introduce the chemical and pharmaceutical properties of the bioactive components from natural sources. Based on the learning, students will understand what natural products chemistry is, and how to apply bioactive natural products in pharmaceutical and cosmeceutical industries.

 

      BooksMedicinal Natural Products A Biosynthetic Approach 3rd Edition, by Paul M Dewick, John Wiley & Sons Ltd (2009).

 

      Handout for undergraduate students

Lecture 1

Introduction to Natural Products Chemistry

2010, 1011 upload

Lecture 2

Biosynthesis Pathway

2010, 1011 upload

Lectures 3&4

Acetate Pathway

2010, 1011 upload

Lecture 5

The Shikimate Pathway

2010, 1102 renew

Lecture 6

The Mevalonate Pathway Terpenoids

2010, 1102 renew

Lecture 7

The Mevalonate Pathway Steroids

2010, 1213 upload

 

Lecture 8

Alkaloids Part I

2010, 1213 upload

Lecture 9

Alkaloids Part II

2011, 0110 upload

 

          Appendix of the Lecture

    Vitamins: P, E, K, A, D, Bs, and C

    Antibiotics: macrolides, tetracyclins, anthracyclines, Chloramphenicol....

 

     BooksNatural product Chemistry 2nd Version by Kurt B. G. Torssell
Apotekarsocieteten-Swedish Pharmaceutical Society, Swedish Pharmaceutical Press (1997).

 

      Handout for graduate students

Lecture 1

Lecture 2

Lecture 3

 

   

Lecture 4

Lecture 5

Lecture 6

 

   

Lecture 7

Lecture 8

Lecture 9

 

Pharmacognosy

     Pharmacognosy is derived from Greek prefix “Pharmakon” and “gnosis”, which means the knowledge about the medicinal materials. The American Society of Pharmacognosy defines pharmacognosy as "the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources." Since the beginning of the 20th century, "pharmacognosy" was used to define the branch of medicine sciences to deal with drugs in their crude, or unprepared, form. Till now, pharmacognosy becomes an interdisciplinary course, including botany, ethnobotany, marine biology, microbiology, herbal medicine, chemistry (phytochemistry), pharmacology and pharmacy practice. More importantly, during the period of time, many chemists and biochemists devoted themselves to the identification of principles of the medicinal materials, which were used to treat human diseases. These studies of chemicals derived from plants, micro-organisms, and even animals discover many new drug candidates derived from natural sources. More than one half of the drugs used in modern medicine are of botanical or natural origin. However, only about 10% of the plants and only 1% of the marine organisms have been properly studied. Therefore, natural products in pharmacognosy can enrich the drug therapy compendia with new safe and effective drugs.

       BooksPharmacognosy and Pharmacobiotechnology by James E. Robbers, Marilyn K. Speedie, Varro E. Tyler, Lippincott Williams & Wilkins Publisher (January 1996)

      Handout

Lecture 1

Introduction to Pharmacognosy

2023, 0318 renew

Lecture 2

Pharmaco-biotechnology

2010, 0310 renew

Lecture 3

Carbohydrates

2010, 0316 renew

Lecture 4

Glycosides

2010, 0407 renew

Lecture 5

Lipids

2010, 0414 renew

Lecture 6

Terpenoids

Parts I

2010, 0504 renew

Lecture 7

Steroids

2010, 0525 renew

Lecture 8

Phenyl-propanoids

2010, 0602 renew

Lecture 9

Alkaloids I & II

2023, 0318 renew

Lecture 10

Alkaloids III & IV

2023, 0318

renew

Lecture 11

Antibiotics I 

2023, 0508 renew

Lecture 12

Antibiotics II

2023, 0508 renew

Lecture 13

Antibiotics III

2023, 0508 renew

Lecture 14

Antibiotics IV 

2023, 0508 renew

Lecture 15

Antibiotics V

2023, 0508 renew

 

 

Lecture 16

Antibiotics VI

2023, 0508 renew

   
 

 

 

 

 

 

 

Supporting Information

 

Supporting info

sugar substitutes

2010, 0323 upload

Lecture 8

Antitumor Natural Drugs

 

 

Spectroscopy:

 

Nuclear Magnetic Resonances

 

Mass

Mass is one of the sensitive tools in the modern chemical analysis. It is applied in the fields of food/drug safety, drug discovery and biological chemistry. Students in the fields of chemistry and life sciences should be have full knowloges about the development and application of Mass technology, which will help them to do a good job on the fields mentioned above.

 

      BooksSpectrometric identification of organic compounds by Robert M. Silverstein, Francis X. Webster (2005).

      Handout

 

 

NMR

Mass

2020, 0425 renew

 

 

Introduction to Marine Resources

      BooksDiscovery and Application of Functional Marine Molecules, 1st edition by R. X. Tan, (science express, Peijing, 2007).

      Handout

 

 

2013, 1115

D&A of Functional Marine Molecules

2013,1204 upload

   

 

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