Laboratory for Marine Chemicobiology
Dr Chih-Chuang Liaw's Lab

at Department of Marine Biotechnology and Resources, National Sun Yat-sen University

20210531 The handouts of Pharmacognosy have been uploaded.

Chih-Chuang Liaw, Ph. D. Professor Highest Education: Graduate Institute of Pharmacy, KMU Major: Natural Products Chemistry Location: MRB4003 Tel: +886-7-5252000#5058 Fax: +886-7-5255020 E-mail: ccliaw@mail.nsysu.edu.tw

2017 Service and Learning Practice of Marine Resources  

      Please remind the Note

Finding Jobs

1.  Research assistants for natural products isolation. Contact me!

2.  Undergraduate students for extraction, identification of secondary metabolites from marine organisms, herbs and medicinal plants. Contact me.

Group meeting schedule

     Group meeting will take place bi-weekly on Thursday in this semester.

Recent publications

1.  Chih-Chuang Liaw,* Yu-Liang Yang, Chun-Kuang Lin, Jin-Ching Lee, Wen-Ying Liao, Chia-Ning Shen, Jyh-Horng Sheu, and Shih-Hsiung Wu,* “New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression”, Org. Lett. 2015, 17, 2330–2333. (IF: 6.364, Chemistry, Organic, 4/57=7.0%)

2.  Chun-Kuang Lin, Chin-Kai Tseng, Kai-Hsun Chen, Shih-Hsiung Wu, Chih-Chuang Liaw,* Jin-Ching Lee,* “Betulinic acid exerts anti-hepatitis C virus activity via the suppression of NF-κB and MAPK-ERK1/2-mediated cyclooxygenase-2 expression”, Br. J. Pharmacol. 2015, 172, 4481-4492. (IF: 4.842, Pharmacology & Pharmacy, 24/254=9.4%)

3.  Chih-Chuang Liaw,* Pei-Chin Chen, Chao-Jen Shih, Sung-Pin Tseng, Ying-Mi Lai, Chi-Hsin Hsu, Pieter C. Dorrestein, and Yu-Liang Yang,* “Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI06 using mass-spectrometry-based metabolomics approach”, Sci. Rep. 2015, 5, 12856; doi: 10.1038/srep12856. (IF: 5.578, Multidisciplinary Sciences, 5/56=8.9%)

4. Ammad Ahmad Farooqi, Kun-Tzu Li, Sundas Fayyaz, Yung-Ting Chang, Muhammad Ismail, Chih-Chuang Liaw, Shyng-Shiou F. Yuan, Jen-Yang Tang,* Hsueh-Wei Chang,* “Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress”, Tumor Biol. 2015, 36, 5743–5752. (IF: 3.611, Oncology, 68/211=32.2%)

5.  Ammad Ahmad Farooqi, Shyh-Jong Wu, Yung-Ting Chang, Jen-Yang Tang, Kun-Tzu Li, Muhammad Ismail, Chih-Chuang Liaw, Ruei-Nian Li,* Hsueh-Wei Chang,* “Activation and inhibition of ATM by phytochemicals: Awakening and sleeping the guardian angel naturally”. Arch. Immunol. Ther. Exp. 2015, 63, 357-366. (IF: 3.176, Immunology, 60/148=40.5%)

6.  Yung-Ting Chang, Chiung-Yao Huang, Kun-Tzu Li, Ruei-Nian Li, Chih-Chuang Liaw, Shih-Hsiung Wu, Jing-Ru Liu, Jyh-Horng Sheu, Hsueh-Wei Chang, Sinuleptolide inhibits proliferation of oral cancer Ca9-22 cells involving apoptosis, oxidative stress, and DNA damage. Arch. Oral Biol. 2016, 66, 147-154.

7.  Mingxun Wang, Jeremy J Carver, Vanessa V Phelan, Laura M Sanchez, Neha Garg, Yao Peng, Don Duy Nguyen, Jeramie Watrous, Clifford A Kapono, Tal Luzzatto-Knaan, Carla Porto, Amina Bouslimani, Alexey V Melnik, Michael J Meehan, Wei-Ting Liu, Max Crüsemann, Paul D Boudreau, Eduardo Esquenazi, Mario Sandoval-Calderón, Roland D Kersten, Laura A Pace, Robert A Quinn, Katherine R Duncan, Cheng-Chih Hsu, Dimitrios J Floros, Ronnie G Gavilan, Karin Kleigrewe, Trent Northen, Rachel J Dutton, Delphine Parrot, Erin E Carlson, Bertrand Aigle, Charlotte F Michelsen, Lars Jelsbak, Christian Sohlenkamp, Pavel Pevzner, Anna Edlund, Jeffrey McLean, Jörn Piel, Brian T Murphy, Lena Gerwick, Chih-Chuang Liaw, Yu-Liang Yang, Hans-Ulrich Humpf, Maria Maansson, Robert A Keyzers, Amy C Sims, Andrew R. Johnson, Ashley M Sidebottom, Brian E Sedio, Andreas Klitgaard, Charles B Larson, Christopher A Boya P., Daniel Torres-Mendoza, David J Gonzalez, Denise B Silva, Lucas M Marques, Daniel P Demarque, Egle Pociute, Ellis C O'Neill, Enora Briand, Eric J. N. Helfrich, Eve A Granatosky, Evgenia Glukhov, Florian Ryffel, Hailey Houson, Hosein Mohimani, Jenan J Kharbush, Yi Zeng, Julia A Vorholt, Kenji L Kurita, Pep Charusanti, Kerry L McPhail, Kristian Fog Nielsen, Lisa Vuong, Maryam Elfeki, Matthew F Traxler, Niclas Engene, Nobuhiro Koyama, Oliver B Vining, Ralph Baric, Ricardo R Silva, Samantha J Mascuch, Sophie Tomasi, Stefan Jenkins, Venkat Macherla, Thomas Hoffman, Vinayak Agarwal, Philip G Williams, Jingqui Dai, Ram Neupane, Joshua Gurr, Andrés M. C. Rodríguez, Anne Lamsa, Chen Zhang, Kathleen Dorrestein, Brendan M Duggan, Jehad Almaliti, Pierre-Marie Allard, Prasad Phapale, Louis-Felix Nothias, Theodore Alexandrov, Marc Litaudon, Jean-Luc Wolfender, Jennifer E Kyle, Thomas O Metz, Tyler Peryea, Dac-Trung Nguyen, Danielle VanLeer, Paul Shinn, Ajit Jadhav, Rolf Müller, Katrina M Waters, Wenyuan Shi, Xueting Liu, Lixin Zhang, Rob Knight, Paul R Jensen, Bernhard O Palsson, Kit Pogliano, Roger G Linington, Marcelino Gutiérrez, Norberto P Lopes, William H Gerwick, Bradley S Moore, Pieter C Dorrestein, Nuno Bandeira. ‘Sharing and community curation of mass spectra by GNPS’, Nat. Biotechnol. 2016 34, 828-837.

8.   Fang-Rong Chang, Shih-Ting Huang, Chih-Chuang Liaw, Ming-Hong Yen,  Tsong-Long Hwang, Ching-Yeu Chen, Ming-Feng Hou, Shyng-Shiou Yuan, Yuan-Bin Cheng,* Yang-Chang Wu,* “Diterpenes from Grangea maderaspatana”, Phytochemistry 2016, 131, 124-129.

9.  Chun-Kuang Lin, Yu-Ting Wang, Er-Mao Hung, Yu-Liang Yang, Jin-Ching Lee, Jyh-horng Sheu, Chih-Chuang Liaw,* “Butyrolactones and Diketopiperazines from Marine Microbes: Inhibition Effects on Dengue Virus Type 2 Replication”, Planta Med. 2017, 83, 158-163.

Book Chapter

1.   Chih-Chuang Liaw, Jing-Ru Liou, Tong-Ying Wu, Fang-Rong Chang, Yang-Chang Wu.* Acetogenins from Annonaceae. In Prog. Chem. Org. Nat. Prod. A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi, Series Title: Progress in the Chemistry of Organic Natural Products; Springer International Publishing: Switzerland; 2016, 101, 113-230. doi: 10.1007/978-3-319-22692-7.

Honors:

1.  2004 Outstanding Graduate Student Award, Kaohsiung Medical University

2.  2008 Poster Presentation Award, The 6th International Symposium for Chinese Medicinal Chemists (ISCMC)

3.  2015 NSYSU-KMU Joint Outstanding Research Award, National Sun Yat-sen University

4.  2016 NSYSU Excellent Research Teacher Award, National Sun Yat-sen University

5.  2016 NSYSU Excellent Teaching Award, National Sun Yat-sen University

6.  2017 NSYSU Excellent Research Teacher Award, National Sun Yat-sen University
 

Highlight:

     The Chemicobiological Study of Marine Microbial Secondary Metabolites in Medicine and Ecology

     Natural Products on the Treatment of Alzheimer's Disease.